p70 S6 Kinase Goat anti-Human, Mouse, Rat, Polyclonal, Invitrogen™
Goat Polyclonal Antibody
Supplier: Thermo Scientific PA131167
PA1-31167 detects S6K1 from human, mouse, and rat, samples. PA1-31167 has been successfully used in Western blot applications. The PA1-31167 immunogen is a synthetic peptide, MISKRPEHLRMNL, corresponding to amino acids 490-502 of S6K1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.The p70 S6 kinase (p70 Ribosomal Protein S6 Kinase, p70S6K) is a 70 kDa member of the ribosomal S6 kinase (RSK) family of serine/threonine kinases. p70 S6 kinase is predomitly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.
|p70 S6 Kinase
|P23443, P67999, Q8BSK8
|synthetic peptide MISKRPEHLRMNL, corresponding to amino acids 490-502 of S6K1.
|Human, Mouse, Rat
|Immunohistochemistry (Paraffin), Western Blot
|PS6K, S6K, S6K1, STK14A, p70(S6K)-alpha, p70-S6K, p70-alpha
|Antigen affinity chromatography
|72508, 83840, 6198
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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