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hnRNP M1-M4 Mouse anti-Bovine, Human, Mouse, Porcine, Rabbit, Rat, Clone: 1D8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA116673

Catalog No. AMPA6673


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Description

Description

Suggested positive control: antigen standard for HNRNPM (transient overexpression lysate).

Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3 ft.-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.
Specifications

Specifications

hnRNP M1-M4
Monoclonal
Unconjugated
HNRNPM
Liquid
HNRNPM
M19 fusion protein containing full-length human protein.
200 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
100356502, 100514153, 116655, 4670, 515290, 76936
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
1D8
ascites with 0.1% sodium azide
P52272, Q9D0E1, Q62826
heterogeneous nuclear ribonucleoprotein M, HNRNPM, HNRNPM4, HNRPM, hnRNA-binding protein M4, HNRNPM3, hnRNA-binding protein M3, HNRNP3, N-acetylglucosamine receptor 1, M4 protein
Mouse
IgG1, kappa
RUO
Antibody
Monoclonal
Bovine, Human, Mouse, Porcine, Rabbit, Rat
SDS
Documents
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