hnRNP M1-M4 Mouse anti-Bovine, Human, Mouse, Porcine, Rabbit, Rat, Clone: 1D8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA116673

Catalog No. AMPA6673

Description

Suggested positive control: antigen standard for HNRNPM (transient overexpression lysate).

Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3 ft.-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.

Specifications

• Antigen: hnRNP M1-M4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: HNRNPM
• Format: Liquid
• Gene Symbols: HNRNPM
• Immunogen: M19 fusion protein containing full-length human protein.
• Quantity: 200 μL
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 100356502, 100514153, 116655, 4670, 515290, 76936

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
• Clone: 1D8
• Formulation: ascites with 0.1% sodium azide
• Gene Accession No.: P52272, Q9D0E1, Q62826
• Gene Alias: heterogeneous nuclear ribonucleoprotein M, HNRNPM, HNRNPM4, HNRPM, hnRNA-binding protein M4, HNRNPM3, hnRNA-binding protein M3, HNRNP3, N-acetylglucosamine receptor 1, M4 protein
• Host Species: Mouse
• Isotype: IgG1, kappa
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Bovine, Human, Mouse, Porcine, Rabbit, Rat