TNPO1 Rabbit anti-Bovine, Canine, Human, Mouse, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141516
DescriptionSAPK interacting protein 1, a stress-activated protein kinase, is an evolutionarily conserved component of the eukaryotic SAPK pathway belonging to the SIN1 family. There are multiple isoforms with one being a 522-amino acid protein with 2 bipartite nuclear localization signals, a peroxisomal targeting signal, and a PEST motif for rapid protein degradation. SAPK interacting protein 1 forms a complex with inactive and nonphosphorylated MEKK2 and in the process regulates its dimerization and activation. It is also known to maintain CRTC2 complex integrity and regulates Akt phosphorylation and cell signaling. Recent reports suggest that it acts as scaffold molecule in the regulation of signaling by JNK and takes part in RAS signal pathway. It expresses in all tissues examined, with highest levels in skeletal muscle and heart.
|Synthetic peptide corresponding to residues 100-150 of human SAPK interacting protein 1.|
|Antigen affinity chromatography|
|Bovine, Canine, Human, Mouse, Rat|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.2% gelatin and 0.05% sodium azide|
|Q3SYU7, Q92973, Q8BFY9|
|SIN-1, MAPKAP1, SIN1, MIP1, MSIN1, mitogen-activated protein kinase associated protein 1, Mitogen-activated protein kinase 2-associated protein 1, SAPK 1, SIN1g, stress-activated protein kinase-interacting 1, stress-activated map kinase interacting protein 1, target of rapamycin complex 2 subunit MAPKAP1, TORC2 subunit MAPKAP1|
|-20° C, Avoid Freeze/Thaw Cycles|
|238799, 309126, 3842, 478093, 767620|
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