SCF Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520746
A suggested positive control is rat brain tissue lysate. PA5-20746 can be used with blocking peptide PEP-0860.Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
|An 18 amino acid peptide from near the center of human SCF.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|P21583, P20826, P21581|
|FPH2, KL-1, Kitl, MGF, SCF, SF, SHEP7, kit-ligand; c-Kit ligand; familial progressive hyperpigmentation 2; kit ligand; mast cell growth factor; steel factor; stem cell factor|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|17311, 4254, 60427|
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