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alpha-ENaC Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen OSR00124W

Catalog No. PIOSR00124W


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Description

Description

SCNN1 is highly expressed in kidney and lung tissues, detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 are predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 are very low or not detectable, except in lung and heart tissues.

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Specifications

Specifications

alpha-ENaC
Polyclonal
whole serum with no preservative
P37088
Epithelial a(+) channel subunit alpha, alpha-ENaC, Nonvoltage-gated sodium channel 1 subunit alpha, alpha-NaCH, SCNN1, FLJ21883, ENaCalpha
Rabbit
IgG
RUO
Antibody
Polyclonal
Human
Immunohistochemistry
Unconjugated
SCNN1A
Lyophilized
SCNN1A
A synthetic peptide from the extracellular domain of human amiloride sensitive sodium channel subunit alpha
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
6337
Documents
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