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FBXL20 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520485

Catalog No. PIPA520485


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Description

Description

A suggested positive control is A-20 cell lysate. PA5-20485 can be used with blocking peptide PEP-0605.

Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
Specifications

Specifications

FBXL20
Polyclonal
Unconjugated
FBXL20
Liquid
FBXL20
An 18 amino acid peptide near the carboxy terminus of the human SCRAPPER.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q96IG2, Q9CZV8, Q9QZH7
Fbl2, Fbl20; F-box protein FBL2; F-box/LRR-repeat protein 20
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
64039, 72194, 84961
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