SCUBE1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520990
A suggested positive control is Daudi cell lysate. PA5-20990 can be used with blocking peptide PEP-1104.SCUBE1 is an EGF-related protein with a CUB (C1s-like) domain that is expressed primarily in the developing gonad, nervous system, somites, surface ectoderm and limb buds. The N-terminal EGF-like repeats of SCUBE1 participate in the formation of adhesions in a Ca2+-dependent fashion. In contrast, the C-terminal cysteine-rich motifs and CUB domain can directly bind and antagonize bone morphogenic protein activity; genetic ablation of this region resulted in brain malformation in mice embryos, suggesting SCUBE1 plays a role in brain morphogenesis. SCUBE1 has also been implicated in early craniofacial development in mice.
|A 14 amino acid peptide near the center of human SCUBE1.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|signal peptide, CUB and EGF-like domain-containing protein 1; signal peptide-CUB domain-EGF-related 1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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