SQSTM1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA118271
PA1-18271 detects Sequestosome 1 from human samples. This antibody is expected to cross react with mouse, rat, and bovine Sequestosome 1, due to sequence homology. PA1-18271 has been successfully used in immunohistochemistry (paraffin) and Western blot procedures. The PA1-18271 immunogen is a synthetic peptide corresponding to the C-terminal residues I(424) G A A L D T I Q Y S K H(436) of human Sequestosome 1, conjugated to the Blue Carrier Protein. After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Reconstitute with 100 µL of distilled water. Glycerol (1:1) may be added for additional stability.Sequestosome 1 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. Sequestosome 1 may play a role in titin/TTN downstream signaling in muscle cells, and may regulate signaling cascades through ubiquitination. Additionally, Sequestosome 1 may be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
|whole serum with no preservative|
|Ubiquitin-binding protein p62, EBI3-associated protein of 60 kDa, p60, EBIAP, SQSTM1|
|Synthetic peptide corresponding to the C-terminal residues I(424) G A A L D T I Q Y S K H(436) of human Sequestosome 1 conjugated to the Blue Carrier Protein.|
|-20° C, Avoid Freeze/Thaw Cycles|
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