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SQSTM1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA118271

Catalog No. 01-670-524


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Description

Description

PA1-18271 detects Sequestosome 1 from human samples. This antibody is expected to cross react with mouse, rat, and bovine Sequestosome 1, due to sequence homology. PA1-18271 has been successfully used in immunohistochemistry (paraffin) and Western blot procedures. The PA1-18271 immunogen is a synthetic peptide corresponding to the C-terminal residues I(424) G A A L D T I Q Y S K H(436) of human Sequestosome 1, conjugated to the Blue Carrier Protein. After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Reconstitute with 100 µL of distilled water. Glycerol (1:1) may be added for additional stability.

Sequestosome 1 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. Sequestosome 1 may play a role in titin/TTN downstream signaling in muscle cells, and may regulate signaling cascades through ubiquitination. Additionally, Sequestosome 1 may be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
Specifications

Specifications

SQSTM1
Polyclonal
whole serum with no preservative
Q13501
Ubiquitin-binding protein p62, EBI3-associated protein of 60 kDa, p60, EBIAP, SQSTM1
Rabbit
IgG
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
Unconjugated
SQSTM1
Lyophilized
SQSTM1
Synthetic peptide corresponding to the C-terminal residues I(424) G A A L D T I Q Y S K H(436) of human Sequestosome 1 conjugated to the Blue Carrier Protein.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8878
Documents
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