SERCA3 ATPase, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1910A
ATP dependent calcium pumps are responsible in part for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are encoded by a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium ATPases (SERCA). The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific isoform expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. SERCA3 has been found to co-express with SERCA2b in platelets, mast cells, lymphoid cells, and epithelial cells. Due to this pattern of expression it is referred to as the non-muscle form of SERCA.PA1-910A detects sarcoplasmic or endoplasmic reticulum calcium ATPase 3 (SERCA3) mouse and rat samples. This antibody does not detect other SERCA isoforms.PA1-910A has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~97kDa protein representing recombinant SERCA3 from rat samples.PA1-910A immunizing peptide corresponds to amino acid residues 29-39 from rat and mouse SERCA3. PA1-910A immunizing peptide (Cat. # PEP-015) is available for neutralization and control experiments.
|Synthetic Peptide: V(29) T D A R E R Y G P N(39).|
|Antigen affinity chromatography|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|Sarcoplasmic or Endoplasmic Reticulum Calcium ATPase 3|
|-20° C, Avoid Freeze/Thaw Cycles|
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