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Serine Racemase Mouse, Unlabeled, Clone: 29, BD

Mouse Monoclonal Antibody

$213.00 - $427.00

Specifications

Antigen Serine Racemase
Isotype IgG1
Immunogen Mouse serine racemase aa. 127-248
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB612052
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BD Biosciences
612052
50μg
Each for $213.00
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BDB612053
View Documents Promotion Details
BD Biosciences
612053
150μg
Each for $427.00
Add to cart
 
Description

Description

The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic. The ionotropic receptors are subdivided into two distinct types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. NMDA receptors require coactivation at both glutamate and glycine sites. D-serine is a D-amino acid found in mammalian tissues that can act as a potent ligand for the glycine site on NMDA receptors. D-serine is made by the enzyme serine racemase, which is a member of the pyridoxal-5′ phosphate (PLP)-dependent enzyme family. Serine racemase mRNA is expressed in brain and liver, and serine racemase protein is expressed in glial cells. Degradation of D-serine by D-amino acid oxidase attenuates NMDA receptor-mediated calcium influx, and implicates D-serine as an endogenouse modulator of NMDA receptor function. Thus, glial cell production of D-serine via serine racemase activity may be an important system for modulation of synaptic transmission.

Host Species: Mouse
Clone: 29
Isotype: IgG1
Species Reactivity [for Features Main]: Mouse
Immunogen: Mouse serine racemase aa. 127-248

Immunofluorescence, Western Blotting

Specifications

Specifications

Serine Racemase
Mouse serine racemase aa. 127-248
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
29
250μg/mL
SDS
Product Certifications

For Research Use Only.

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