STRAP Rabbit anti-Bovine, Canine, Equine, Human, Mouse, Non-human primate, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523165
DescriptionSTRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
|Synthetic peptide (241 GGEDFKLYKYDYNSGEELES 260) of Serine/Threonine Kinase Receptor Associated Protein protein.|
|Bovine, Canine, Equine, Human, Mouse, Non-human primate|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.2% gelatin and 0.05% sodium azide|
|Q5E959, Q9Y3F4, Q9Z1Z2|
|MAWD, PT-WD, UNRIP, MAP activator with WD repeats, WD-40 repeat protein PT-WD, serine-threonine kinase receptor-associated protein, unr-interacting protein|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|100067410, 11171, 20901, 486663, 510201|
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