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STRAP Rabbit anti-Bovine, Canine, Equine, Human, Mouse, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523165

Catalog No. PIPA523165


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Description

Description

STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
Specifications

Specifications

STRAP
Polyclonal
Unconjugated
STRAP
Liquid
STRAP
Synthetic peptide (241 GGEDFKLYKYDYNSGEELES 260) of Serine/Threonine Kinase Receptor Associated Protein protein.
Protein G
RUO
Antibody
Polyclonal
Bovine, Canine, Equine, Human, Mouse, Non-human primate
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
Q5E959, Q9Y3F4, Q9Z1Z2
MAWD, PT-WD, UNRIP, MAP activator with WD repeats, WD-40 repeat protein PT-WD, serine-threonine kinase receptor-associated protein, unr-interacting protein
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100067410, 11171, 20901, 486663, 510201
Documents
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