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HTR1B Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141069

Catalog No. 01-676-664



Description

Description

Suggested positive control: human, mouse, or rat brain.

Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase (2). Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. In situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.
Specifications

Specifications

HTR1B
Polyclonal
Unconjugated
HTR1B
Liquid
HTR1B
Synthetic peptides corresponding to residues 8-26 and 263-278 of rat 5-HT1BR.
Protein G
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1.0 mg/mL
PBS with 0.05% sodium azide
P28222, P28334, P28564
5-HT1B
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
15551, 25075, 3351
Documents
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