SETD7 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141119
These sequences are 100% conserved between human, mouse and rat. Suggested positive control: Hela whole cell extract, HeLa cell lysate.Diverse signal transduction pathways impinging on the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly(ADP-ribosylation), ubiquitination and methylation. These modifications play critical roles in regulating chromatin structure and gene expression. Histone methyltransferases (HMTases) selectively methylate evolutionarily conserved arginine or lysine residues, primarily in the N-terminal tails of histones H3 and H4. Set7/9 is a histone specific HMTase that methylates histone H3 lysine 4. Set7/9 transfers methyl groups to lysine 4 of histone H3 in complex with S-adenosyl-L-methionine. Human Set7/9 is a 336 amino acid protein.
|whole serum diluted in PBS with 0.05% sodium azide|
|ChIP assay, Immunohistochemistry (Paraffin), Western Blot|
|Synthethic peptides corresponding to residues G(131) E V N E D G E M T G E K I A(145) and G(336) Y D H S P P G K S G P E A P E W(352) of human Set7/9.|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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