MilliporeSigma anti-SGLT-1, Polyclonal, (Upstate)
Manufacturer: MilliporeSigma 071417/DEL
The kidneys play a major role in the regulation of blood glucose. Although kidney nephrons indiscriminatly filter about 180g of glucose per day from the blood, most is reabsorbed actively in the proximal convoluted tubule by a Na+/Gl co-transport (ratio 2:1) mechanism (SGLT). Typically, glucose is first reabsorbed by these transporters, which reside within the brush-border epithelia of the PCT cells. The glucose is then transported out of the cell across the basolateral membranes by a facilitated diffusion sugar transporter (GLUTs). At least three members of SGLT's (SGLT1-3) have been cloned and characterized from various species. SGLT1-3 genes code for protein of approximately 659-672 residues, with both N and C termini predicted to be extracellular. There is approximately 60-70% homology between the 3 forms. SGLT1 does not discriminate a-MDG, glucose and galactose, while SGLT2 and 3 do not transport D-galactose efficiently. SGLT1 is an integral membrane protein expressed in proximal convoluted tubule Sq1 segments of the kidney (outer renal medulla) and in the intestine.
Species Reactivity:Dog, Human, Mouse, Porcine, Rat, Rabbit, Feline, Avian, Reptile
Immunogen:Synthetic peptide corresponding to amino acids 402-420 of the putative etracellular loop of SGLT-1 of mouse/rabbit small intestine.
Molecular Weight:Recognizes a band of approimately 70-77kDa in Western blot.
ELISA, Immunohistochemistry (Paraffin), Western Blotting
|Avian, Canine, Feline, Human, Murine, Porcine, Rabbit, Rat, Reptile|
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