Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ anti-SGLT-1, Polyclonal, ™ (Upstate™) Non-distribution product as customer accommodation.

Manufacturer:  MilliporeSigma™ 071417/DEL

Catalog No. 50-172-256

This item has been discontinued and is no longer available. Please call customer service for assistance: 1-800-766-7000.
View substitute products »


Description

Description

The kidneys play a major role in the regulation of blood glucose. Although kidney nephrons indiscriminatly filter about 180g of glucose per day from the blood, most is reabsorbed actively in the proximal convoluted tubule by a Na+/Gl co-transport (ratio 2:1) mechanism (SGLT). Typically, glucose is first reabsorbed by these transporters, which reside within the brush-border epithelia of the PCT cells. The glucose is then transported out of the cell across the basolateral membranes by a facilitated diffusion sugar transporter (GLUTs). At least three members of SGLT's (SGLT1-3) have been cloned and characterized from various species. SGLT1-3 genes code for protein of approximately 659-672 residues, with both N and C termini predicted to be extracellular. There is approximately 60-70% homology between the 3 forms. SGLT1 does not discriminate a-MDG, glucose and galactose, while SGLT2 and 3 do not transport D-galactose efficiently. SGLT1 is an integral membrane protein expressed in proximal convoluted tubule Sq1 segments of the kidney (outer renal medulla) and in the intestine.

Host Species:Rabbit
Clone:
Isotype:IgG
Species Reactivity:Dog, Human, Mouse, Porcine, Rat, Rabbit, Feline, Avian, Reptile
Epitope:
Immunogen:Synthetic peptide corresponding to amino acids 402-420 of the putative etracellular loop of SGLT-1 of mouse/rabbit small intestine.
Molecular Weight:Recognizes a band of approimately 70-77kDa in Western blot.

ELISA, Immunohistochemistry (Paraffin), Western Blotting

Specifications

Specifications

SGLT-1
Serum
IgG
RUO
Primary
Avian, Canine, Feline, Human, Murine, Porcine, Rabbit, Rat, Reptile
Unconjugated
Rabbit
100μL
Cell Signaling
Polyclonal
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit