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Bif1 Goat anti-Human, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA19017

Catalog No. 01-674-601


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Description

Description

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by the activation of proteolytic enzymes termed caspases. Proteins that comprise the Bcl-2 family such as Bax appear to control the activation of these enzymes. Bax activity was found to be regulated by its association with Bax-interacting factor 1 (BIF), a member of the endophilin B family that is associated with intracellular membranes. Following this interaction, Bax undergoes a conformational change and translocates to mitochondrial membranes. The Bax/BIF interaction appears to be enhanced by apoptotic stimuli, suggesting that BIF acts as the trigger to activate Bax, and as suppression of BIF promoted HeLa cell colony formation in soft agar, it may have a role in the suppression of cancer progression. At least two isoforms of BIF are known to exist.

This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
Specifications

Specifications

Bif1
Polyclonal
Unconjugated
SH3GLB1
Liquid
SH3GLB1
Synthetic peptide corresponding to the C terminus amino acids QKGKVPITYLELLN.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry, peptide-ELISA, Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Q9Y371
BIF1, Bif-1, CGI-61, KIAA0491, dJ612B15.2
Goat
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
51100
Documents
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