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ShcC Mouse, Unlabeled, Clone: 23, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610642

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Catalog No. BDB610642

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Mammalian ShcA is expressed as three proteins of 46kDa, 52kDa, and 66kDa. Each protein contains a C-terminal SH2 domain, a central glycine/proline rich sequence, and an N-terminal phosphotyrosine-binding domain (PTB). All three Shc proteins become tyrosine phosphorylated by activated growth factor receptors and oncogene tyrosine kinases. Two additional murine genes with Shc homology have been identified and named ShcB and ShcC. The ShcC gene encodes a protein of 475 amino acids and mobility of 55kDa. Additional immunoreactive proteins have been observed with apparent molecular weights of 69kDa and 100kDa. These could be due to extended 5 ft. sequences in the ShcC gene. In contrast to widely distributed ShcA proteins, expression of ShcC is restricted to the nervous system and spleen.

Immunofluorescence, Immunoprecipitation, Western Blotting



Affinity Purified
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Cell Biology
Human, Murine, Rat
Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
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