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Shiga like-toxin 1 Mouse anti-Bacteria, Clone: 13C4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA140277

Catalog No. 01-676-396


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Description

Description

MA1-40277 detects Shigatoxin 1 from E. coli samples. MA1-40277 has been successfully used in ELISA, functional assays and Western blot applications. The MA1-40277 immunogen is 1B subunit of Shigatoxin 1.

Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11 and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share 99% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct. The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.
Specifications

Specifications

Shiga like-toxin 1
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and no preservative
SLT-1; SLT-I; SLT1; SLTI; Verotoxin; Verocytotoxin
1B subunit of Shigatoxin 1.
Protein G
RUO
Antibody
Monoclonal
ELISA, Functional Assay, Western Blot
13C4
Unconjugated
Liquid
Mouse
IgG1
100 μg
4° C
Primary
Bacteria
Documents
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