SHIP-1/p150[ship] Mouse, Unlabeled, Clone: 32, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611334
Tyrosine kinase receptors control the growth, survival, differentiation, and expression of mature hematopoietic cell functions. Activation of these receptors leads to Tyr phosphorylation of specific residues that are bound by SH-2 domain containing proteins like GRB2, SHC, p85/PtdIns-3-kinase, or SH2-containing inositol phosphatases (SHIPs). These adaptor proteins regulate the activity of downstream effectors either through interaction with SH-3 domains or through enzymatic modification. SHIPs include SHIP-1 (p150[Ship]) and SHIP-2. SHIP-1 is
an inositol polyphosphate-5-phosphatase that contains one SH2 domain, two potential phosphotyrosine-binding domains, an ATP/GTP-binding domain, and several potential SH-3-binding sites. It is co-expressed in spleen, thymus, and lung with SHIP-2. While SHIP-1 is involved in negative regulation of macrophage cell growth, it functions in B cell activation. Thus, through interactions with other adaptor proteins or its enzymatic function, SHIP-1 is an essential component of receptor tyrosine kinase pathways that control hematopoietic cell function.
Host Species: Mouse
Species Reactivity: Rat
Immunogen: Mouse p150 [SHIP] aa. 16-135
Formula Weight [Chemical]: 150kDa
Immunofluorescence, Western Blotting
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|Mouse p150 [SHIP] aa. 16-135|
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