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SHP2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520278

Catalog No. PIPA520278

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A suggested positive control is mouse skeletal muscle tissue lysate. PA5-20278 can be used with blocking peptide PEP-0408.

Src homology-2 domain containing protein (SHP2) is a member of the protein tyrosine phosphatase (PTP) family, a protein family that contains signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. SHP2 contains two tandem Src homology-2 (SH2) domains, which function as phosphotyrosine binding domains either directly or through scaffolding intermediates such as the insulin-receptor substrate 1 (IRS-1). These SH2 domains mediate the interaction of SHP2 with its substrates, allowing SHP2 to dephosphorylate proteins that inhibit signaling kinases such as ERK1 and AKT. SHP2 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Recent experiments have shown SHP2 plays a significant role in hepatoprotection and liver regeneration.


A 14 amino acid peptide from near the carboxy terminus of human SHP2.
Antigen affinity chromatography
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q06124, P35235, P41499
BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; tyrosine-protein phosphatase non-receptor type 11
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
19247, 25622, 5781
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