SIAH1 Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112863
A suggested positive control for this product is human brain lysate.Seven in absentia homolog 1 (SIAH-1) is a member of the RINGfinger- containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinson′s disease (PD). Mutations in Parkin, another E3 ubiquitin ligase which ubiquinates synphilin-1 and glycosylated alpha-synuclein, have been defined as a major cause of autosomal recessive PD. The role of SIAH-1 in PD is highlighted by the fact that SIAH-1 is a component of the Lewy bodies and plays a role in apoptosis caused by nitric oxide (NO) induced oxidative stress.
|PBS with 0.08% sodium azide|
|HUMSIAH, Siah-1, Siah-1a, hSIAH1|
|-80° C, Avoid Freeze/Thaw Cycles|
|Synthetic peptide corresponding to human SIAH-1.|
|Antigen affinity chromatography|
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