anti-SIAH1, E3 Ubiquitin Ligase Polyclonal, Thermo Scientific™

SIAH1, E3 Ubiquitin Ligase Polyclonal Ab PA1-12861 from Thermo Scientific™ specifically detects SIAH1, E3 Ubiquitin Ligase in Hu samples, and it is validated for WB

Manufacturer: Invitrogen PA112863

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Catalog No. 01-675-843

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    Specifications

    Antigen SIAH1, E3 Ubiquitin Ligase
    Applications Western Blotting
    Conjugate Unlabeled
    Cross Reactivity Human
    Format Purified
    Formulation 50μg purified antibody in PBS and 0.08% sodium azide
    Gene Accession No. Q8IUQ4
    Gene Alias HUMSIAH, Siah-1, Siah-1a, hSIAH1
    Gene Symbols SIAH1
    Host Species Rabbit
    Immunogen Synthetic peptide corresponding to human SIAH-1.
    Isotype IgG
    Quantity 50μg
    Species Reactivity Human
    Storage Requirements Avoid Freeze/Thaw Cycles
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal
    Gene ID (Entrez) 6477

    SIAH1, E3 Ubiquitin Ligase Polyclonal Ab PA1-12861 from Thermo Scientific™ specifically detects SIAH1, E3 Ubiquitin Ligase in Hu samples, and it is validated for WB

    Seven in absentia homolog 1 (SIAH-1) is a member of the RINGfinger- containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinson's disease (PD). Mutations in Parkin, another E3 ubiquitin ligase which ubiquinates synphilin-1 and glycosylated alpha-synuclein, have been defined as a major cause of autosomal recessive PD. The role of SIAH-1 in PD is highlighted by the fact that SIAH-1 is a component of the Lewy bodies and plays a role in apoptosis caused by nitric oxide (NO) induced oxidative stress.
    Host Species: Rabbit
    Cross Reactivity: Human
    Isotype: IgG
    Immunogen: Synthetic peptide corresponding to human SIAH-1.
    Formulation: 50µg purified antibody in PBS and 0.08% sodium azide
    Synonyms: HUMSIAH, Siah-1, Siah-1a, hSIAH1
    Uniprot Accession: Q8IUQ4
    Entrez GeneID: 6477
    Gene Symbol: SIAH1
    A suggested positive control for this product is human brain lysate.

  • Description & Specifications

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