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SIGIRR Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA528244

Catalog No. PIPA528244


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Description

Description

PA5-28244 targets SIGIRR in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-28244 immunogen is recombit fragment corresponding to a region within amino acids 54 and 410 of Human SIGIRR. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Specifications

Specifications

SIGIRR
Polyclonal
Unconjugated
SIGIRR
Liquid
SIGIRR
Recombit fragment corresponding to a region within amino acids 54 and 410 of Human SIGIRR
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Q6IA17
TIR8, single Ig IL-1-related receptor, single Ig IL-1R-related molecule, single immunoglobulin domain IL1R1 related, single immunoglobulin domain-containing IL1R-related protein, toll/interleukin-1 receptor 8
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
59307
Documents
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