SIGIRR Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528244
PA5-28244 targets SIGIRR in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-28244 immunogen is recombit fragment corresponding to a region within amino acids 54 and 410 of Human SIGIRR. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
|Recombit fragment corresponding to a region within amino acids 54 and 410 of Human SIGIRR|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7|
|TIR8, single Ig IL-1-related receptor, single Ig IL-1R-related molecule, single immunoglobulin domain IL1R1 related, single immunoglobulin domain-containing IL1R-related protein, toll/interleukin-1 receptor 8|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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