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Siglec-5/Siglec-14 Mouse anti-Human, Alexa Fluor 647, Clone: 194128, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564371

Catalog No. BDB564371

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The 194128 monoclonal antibody specifically binds to Siglec-5 (Sialic acid binding Ig-like lectin 5) and Siglec-14 (Sialic acid-binding Ig-like lectin 14). Siglec-5 is also known as CD170, CD33 antigen-like 2 (CD33L2) and OBBP2 (OB binding protein-2) whereas Siglec-14 is also referred to as SIG14. Both molecules are type I transmembrane glycoproteins that belong to the SIGLEC (sialic acid binding Ig-like lectin) family within the immunoglobulin superfamily. Siglec-5 can bind to alpha-2, 3- and alpha-2, 6-linked sialic acid glycoproteins and glycolipids. It is highly expressed on neutrophils and expressed at lower levels by monocytes/macrophages and dendritic cells. Siglec-5 can function as an inhibitory receptor for some cellular responses and enhance the anti-phagocytic responses by some macrophages. Siglec-14 has 99.5% amino acid sequence homology with Siglec-5 within their first two extracellular Ig domains and has a similar ligand binding preference. Siglec-14 is expressed by cells of myeloid origin and serves as an activating receptor.



CD170; SIGLEC5; SIGL5; CD33L2; OB-BP2 and SIGLEC14; SIG14
Affinity Purified
Human Siglec-5 Recombinant Protein
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Flow Cytometry
Alexa Fluor 647
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IgG1, κ
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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