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SIN3A Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1870

Catalog No. PA1870


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Description

Description

PA1-870 detects mSin3A from human and mouse tissues and cells. PA1-870 has been successfully used in Western blot, ICC/IF ChIP, IHC-P and immunoprecipitation procedures. By Western blot, this antibody detects an ~150 kDa protein representing mSin3A from T47D cell extract. PA1-870 immunogen is a synthetic peptide corresponding to residues M(1) K R R L D D Q E S D V Y A A Q Q R R(19) of mouse mSin3A. This immunizing peptide (Cat. No. PEP-108) is available for use in neutralization and control experiments.

Mammalian Sin3 (mSin3) is a 150 kDa protein closely related to the yeast SIN3 repressor protein involved in the transcriptional repression of many genes. There are two mammalian isoforms, mSin3A and mSin3B. Containing 4 paired amphipathic helix domains (PAH domains), mSin3A and mSin3B have been shown to directly interact with several other transcriptional repressor proteins including HDAC1, HDAC2, RbAp46, the methyl CpG binding protein MeCP2, the Mad/Max heterodimer, and the corepressors silencing mediator of retinoic acid & thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR).
Specifications

Specifications

Sin3A
Polyclonal
Unconjugated
SIN3A
Liquid
SIN3A
Synthetic peptide corresponding to residues M(1) K R R L D D Q E S D V Y A A Q Q R R(19) of mouse mSin3A.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
ChIP assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
Q96ST3, Q60520
Mammalian Sin3A, SIN
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
20466, 25942
Documents
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