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Prosapip2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523223

Catalog No. PIPA523223


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Description

Description

SINTBAD is an adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It is essential for signal transduction during viral infection and plays a major role in the NF-kB pathway. SINTBAD is thus required for efficient IRF (interferon regulatory factor) activation by Sendai virus. The protein binds TBK1 (TANK-binding kinase) and IKKi (inhibitor of nuclear factor  B kinase, inducible) via a newly identified TBK1/IKKi-binding domain (TBD), which it shares with TANK and NAP1. Binding to kinases via TBD is essential for IRF3 (interferon regulatory factor 3) activation which controls the expression of antiviral genes during infection. The protein has a ubiquitous expression with highest levels in ovary, followed by testis and brain. Human SINTBAD gene is mapped to chromosome 17q21.32.
Specifications

Specifications

Prosapip2
Polyclonal
Unconjugated
TBKBP1
Liquid
TBKBP1
Synthetic peptide (328 RSGGQRHSPLSQRHSPAPQC 347) of SINTBAD/TBKBP1 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
A7MCY6, A2A9T0, Q6DG50
ProSAPiP2, SINTBAD, TANK-binding kinase 1-binding protein 1, TBK1-binding protein 1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
266764, 73174, 9755
Documents
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