Prosapip2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523223
DescriptionSINTBAD is an adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It is essential for signal transduction during viral infection and plays a major role in the NF-kB pathway. SINTBAD is thus required for efficient IRF (interferon regulatory factor) activation by Sendai virus. The protein binds TBK1 (TANK-binding kinase) and IKKi (inhibitor of nuclear factor B kinase, inducible) via a newly identified TBK1/IKKi-binding domain (TBD), which it shares with TANK and NAP1. Binding to kinases via TBD is essential for IRF3 (interferon regulatory factor 3) activation which controls the expression of antiviral genes during infection. The protein has a ubiquitous expression with highest levels in ovary, followed by testis and brain. Human SINTBAD gene is mapped to chromosome 17q21.32.
|Synthetic peptide (328 RSGGQRHSPLSQRHSPAPQC 347) of SINTBAD/TBKBP1 protein.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|A7MCY6, A2A9T0, Q6DG50|
|ProSAPiP2, SINTBAD, TANK-binding kinase 1-binding protein 1, TBK1-binding protein 1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|266764, 73174, 9755|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok