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Gemin 2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520978

Catalog No. PIPA520978


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Description

Description

A suggested positive control is Hela cell lysate. PA5-20978 can be used with blocking peptide PEP-1092.

SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.
Specifications

Specifications

Gemin 2
Polyclonal
Unconjugated
GEMIN2
Liquid
GEMIN2
A 19 amino acid peptide near the carboxy terminus of human SIP1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O14893, Q9CQQ4, Q9QZP1
SIP1, SIP1-delta; SMN interacting protein 1-delta; component of gems 2; gem-associated protein 2; gemin-2; survival of motor neuron protein interacting protein 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
66603, 84404, 8487
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