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SIPA1L1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520847

Catalog No. PIPA520847


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Description

Description

A suggested positive control is rat brain tissue lysate. PA5-20847 can be used with blocking peptide PEP-0961.

Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
Specifications

Specifications

SIPA1L1
Polyclonal
Unconjugated
SIPA1L1
Liquid
SIPA1L1
A 16 amino acid peptide from near the amino terminus of human SIPA1L1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O43166, Q8C0T5, O35412
E6TP1; E6-targeted protein 1; H_DJ1140G11.1; SIPA1-like protein 1; WUGSC:H_DJ1140G11.1; high-risk human papilloma viruses E6 oncoproteins targeted protein 1; signal-induced proliferation-associated 1-like 1; signal-induced proliferation-associated 1-like protein 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
217692, 246212, 26037
Documents
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