SIPA1L1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520847
A suggested positive control is rat brain tissue lysate. PA5-20847 can be used with blocking peptide PEP-0961.Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
|A 16 amino acid peptide from near the amino terminus of human SIPA1L1.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|O43166, Q8C0T5, O35412|
|E6TP1; E6-targeted protein 1; H_DJ1140G11.1; SIPA1-like protein 1; WUGSC:H_DJ1140G11.1; high-risk human papilloma viruses E6 oncoproteins targeted protein 1; signal-induced proliferation-associated 1-like 1; signal-induced proliferation-associated 1-like protein 1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|217692, 246212, 26037|
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