SIRT1 Chicken anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Chicken Polyclonal Antibody
Manufacturer: Invitrogen PA520964
A suggested positive control is mouse liver tissue lysate. PA5-20964 can be used with blocking peptide PEP-1078.The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically via lysine residue.
|A 19 amino acid peptide near the amino terminus of human SIRT1.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q96EB6, Q923E4, A0A0G2JZ79|
|RP11-57G10.3, SIR2L1; NAD-dependent deacetylase sirtuin-1; SIR2-like protein 1; SIR2alpha; hSIR2; hSIRT1; sir2-like 1; sirtuin type 1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|23411, 309757, 93759|
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