SIRT2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA3200
PA3-200 detects human and rat SIRT2 and shows no cross-reactivity to other SIRT isoforms. PA3-200 has been successfully used in Western blot and immunocytochemistry procedures. By Western blot, this antibody detects an ~48 kDa protein representing SIRT2 from SAOS2 cells. PA3-200 can be used for immunocytochemistry procedures. PA3-200 immunizing peptide corresponds to amino acid residues 341-352 from the human SIRT2 protein. This sequence is completely conserved between human and rat.The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.
|whole serum with 0.05% sodium azide|
|Q8IXJ6, Q8VDQ8, Q5RJQ4|
|Sirtuin for Silent Mating Type Information 2-Homolog|
|-20° C, Avoid Freeze/Thaw Cycles|
|22933, 361532, 64383|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Synthetic Peptide: D(341) E A R T T E R E K P Q(352)|
|Human, Mouse, Rat|
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