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SIRT2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520487

Catalog No. PIPA520487


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Description

Description

A suggested positive control is mouse brain tissue lysate. PA5-20487 can be used with blocking peptide PEP-0607.

The founding member of the sirtuin protein family was the silent information regulator 2 protein (Sir2p) of Saccharomyces cervisiae, an NAD+-dependent histone deacetylase (HDAC) that regulates chromatin silencing. The SIR2 family of genes are highly conserved from prokaryotes to eukaryotes. Mammals have seven homologs of Sir2p, SIRT1-7, which are involved in diverse processes ranging from transcriptional regulation, cell cycle progression and DNA-damage repair to aging. SIRT2 is a predomitly cytoplasmic protein that colocalizes with microtubules and can deacetylate alpha-tubulin and regulate progression through the cell cycle. Most Sirtuins are highly expressed in brain and testis, while Sirt2 expression is higher in fetal relative to adult brain. Recent studies on SIRT2 support the therapeutic utility of inhibitors for the treatment of neurodegenerative diseases such as Parkinson ft.s disease.
Specifications

Specifications

SIRT2
Polyclonal
Unconjugated
SIRT2
Liquid
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
22933, 361532, 64383
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q8IXJ6, Q8VDQ8, Q5RJQ4
SIRT2
A 19 amino acid peptide near the carboxy terminus of the human SIRT2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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