SIRT5 Chicken anti-Human, Mouse, Polyclonal, Invitrogen
Chicken Polyclonal Antibody
Manufacturer: Invitrogen PA520966
A suggested positive control is human liver tissue lysate. PA5-20966 can be used with blocking peptide PEP-1080.The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT5 localizes to mitochondria, deacetylates carbamoyl phosphate synthetase 1, and is involved in the regulation of the urea cycle.
|A 17 amino acid peptide near the carboxy terminus of human SIRT5.|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|SIR2L5; NAD-dependent deacetylase sirtuin-5; SIR2-like protein 5; silent mating type information regulation 2, S.cerevisiae, homolog 5; sir2-like 5; sirtuin type 5|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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