SIRT6 Chicken anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Chicken Polyclonal Antibody
Manufacturer: Invitrogen PA520967
A suggested positive control is Hela cell lysate. PA5-20967 can be used with blocking peptide PEP-1081.The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT6 is a histone H3 lysine 9 deacetylase and is thought to stabilize the DNA-dependent protein kinase at double-stranded DNA breaks and may have a role in the process of mammalian aging.
|A 17 amino acid peptide near the carboxy terminus of human SIRT6.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|PBS with 0.02% sodium azide|
|SIR2L6; NAD-dependent deacetylase sirtuin-6; SIR2-like protein 6; sir2-related protein type 6; sirtuin type 6|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|299638, 50721, 51548|
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