SIT Mouse anti-Human, Clone: SIT-01, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119285
DescriptionSIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.
|Bacterially produced, recombit, intracellular fragment of human SIT.|
|Flow Cytometry, Immunoprecipitation, Western Blot|
|PBS with 15mM sodium azide; pH 7.4|
|MGC125908, MGC125909, MGC125910, RP11-331F9.5, SIT|
|4° C, do not freeze|
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