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SKA1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520817

Catalog No. PIPA520817


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Description

Description

A suggested positive control is A549 cell lysate. PA5-20817 can be used with blocking peptide PEP-0931.

Upon entry into mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintece of the metaphase plate and spindle checkpoint silencing.
Specifications

Specifications

SKA1
Polyclonal
Unconjugated
SKA1
Liquid
SKA1
A 13 amino acid peptide from near the carboxy terminus of human SKA1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q96BD8, Q9CPV1, B0BN28
C18orf24; spindle and KT (kinetochore) associated 1; spindle and kinetochore-associated protein 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
220134, 291441, 66468
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