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SnoN Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141293

Catalog No. 01-675-634


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Description

Description

Principal Names: SnoN; SNO; SKI-like; Ski-related Oncogene; SnoA; SKIL Official Gene Symbol- SKIL Gen Bank Accession Number- NP_005405 Gene ID- 6498(Human) 20482 (mouse) Gene Map Locus- 3q26 (human) SnoN, an 80kDa protein, is a member of ski family of nuclear proto-oncogenes involved in regulation of cellular transformation and differentiation. Primarily expressed in two isoforms, SnoN is localized in cytoplasm in normal tissues and non-tumorigenic primary epithelial cells. In cancer tissues or cells, SnoN is exclusively localized in the nucleus. It plays a vital role in inhibition of cell cycle arrest induced by TGF-â. Upon morphological differentiation or cell-cycle arrest, SnoN translocates into the nucleus, binds to Smad2, Smad3, and Smad4 on TGF- -responsive promoters and represses their ability to activate expression of TGF-  target genes. It has also been found to mediate transcriptional repression of thyroid hormone receptor, Mad and pRb. Increased expression of SnoN has been detected in many human tumor cell lines suggesting a clinical significance.

Specifications

Specifications

SnoN
Polyclonal
Unconjugated
PBS with 0.05% BSA and 0.05% sodium azide
P12757, Q60665
SKIL,SnoN
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
114208, 20482, 6498
Western Blot
0.5 mg/mL
1-3ug/mL
SKIL
Liquid
SKIL
Synthetic peptide corresponding to residues 600-684 of human snoN.
Protein G
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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