CD150 Mouse anti-Human, Clone: IPO-3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA17626
MA1-7626 detects SLAM from human samples. MA1-7626 has been successfully used in ELISA, flow cytometry, Immunohistochemistry and Immunoprecipitation procedures. The MA1-7626 immunogen is an activated B cell line. Store at 4°C short term. For long term storage, store at -80°C.CD150 (SLAM, Signaling Lymphocyte Activation Molecule) belongs to the immunoglobulin gene superfamily, and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form, the soluble form and the cytoplasmic isoforms of SLAM. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells. Moreover, CD150 is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations CD150 gene may be associated with X-linked lympho-proliferative disease (XLP).
|PBS with no preservative; pH 7.2|
|CD150, CDw150, SLAM, IPO-3, signaling lymphocytic activation molecule, SLAMF1|
|4°C or -80°C if preferred|
|ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation|
|Activated B cell line.|
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