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SLA Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523294

Catalog No. PIPA523294


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Description

Description

SLAP also known as Src-like-adapter protein 1 is a 276 amino acid containing adapter protein, functioning as a negative regulator of T-cell receptor (TCR) signaling. SLAP belonging to the SRC family of cytoplasmic tyrosine kinases contains a SH2 domain and a SH3 domain. This cytoplasmic protein colocalizes with endosomes and is known to inhibit T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. It acts as a negative regulator of positive selection and mitosis of T-cells. SLAP may act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Expression of SLAP is weak in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas but is high in lung and fetal brain.
Specifications

Specifications

SLA
Polyclonal
Unconjugated
SLA
Liquid
SLA
Synthetic peptide (TLRQKTVDWRRVSRLQED (aa193-210)) of SLAP protein.
Protein A
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q13239
SLA1, SLAP, SLAP-1, hSLAP, src-like-adapter, src-like-adapter protein 1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
6503
Documents
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