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SLC35D1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520554

Catalog No. PIPA520554


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Description

Description

A suggested positive control is A-20 cell lysate. PA5-20554 can be used with blocking peptide PEP-0674.

The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.
Specifications

Specifications

Slc35D1
Polyclonal
Unconjugated
SLC35D1
Liquid
SLC35D1
A 14 amino acid peptide near the amino terminus of the human Slc35D1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9NTN3, A2AKQ0
UGTREL7; UDP-GlcA/UDP-GalNAc transporter; UDP-galactose transporter-related 7; UDP-galactose transporter-related protein 7; UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; solute carrier family 35 member D1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
23169, 242585, 298280
Documents
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