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SLITRK2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520472

Catalog No. PIPA520472


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Description

Description

A suggested positive control is mouse brain tissue lysate. PA5-20472 can be used with blocking peptide PEP-0592.

SLIT and NTRK-like family 2 (Slitrk2) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk2 is expressed primarily in neurons in the ventricular layer of the brain. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk2 inhibited neurite outgrowth in cultured neurons. Deletion analysis indicated that the functional difference between Slitrk2 and Slitrk1 is within their intracellular domains. At least two isoforms of this protein are known to exist.
Specifications

Specifications

Slitrk2
Polyclonal
Unconjugated
SLITRK2
Liquid
SLITRK2
A 16 amino acid peptide from near the center of human Slitrk2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9H156, Q810C0
UNQ9197/PRO34756, CXorf2, SLITL1; SLIT and NTRK-like protein 2; slit and trk like gene 2; slit-like 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
245450, 309349, 84631
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