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SLP-76 Mouse anti-Human, Unlabeled, Clone: 8, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610736

Catalog No. BDB610736


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Description

Description

SLP-76 (SH2 domain-containing Leukocyte Protein) is a tyrosine phosphoprotein that is involved in the TCR mediated intracellular signaling pathway. It may be involved in the signaling pathways of peripheral blood leukocytes, thymic/splenic cells, and in human T, B, and monocytic cell lines. SLP-76 consists of several motifs that signify its importance in protein-protein interactions involved in intracellular signaling pathways, such as the SH2 domain in the C-terminus, the amino-terminus three 17-amino acid repeats with conserved tyrosine and acidic
residues (DYE(S/P)P), and a proline rich region. SLP-76 has been shown to associate with Grb2, PLC-γ, SLAP-130, and Vav-all of which are part of the signaling cascade in T cells. ZAP-70 appears to phosphorylate SLP-76, allowing phosphorylated Vav to bind and, together the SLP-76/Vav complex, cooperatively stimulates NF-AT and IL-2 gene activation. Overexpression of SLP-76 has been reported to increase the TCR-mediated transcription of the IL-2 gene. Furthermore, SHP-1 associates with SLP-76 in normal splenic B cells which suggests a role for SLP-76 in BCR signaling.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

SLP-76
8
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
SH2 domain-containing Leukocyte Protein
Affinity Purified
Human SLP-76 aa. 369-520
50μg
Cell Biology
Primary
Human
Documents
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