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SLP76 Mouse anti-Human, Clone: AS55, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112902

Catalog No. 01-674-099

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
Specifications

Specifications

SLP76
Monoclonal
Unconjugated
LCP2
Liquid
LCP2
Recombit human SLP-76 fusion protein.
Protein A/G
RUO
Antibody
Monoclonal
Human
Immunoprecipitation, Western Blot
AS55
PBS with 0.08% sodium azide
Q13094
LCP2, SLP76, LCP2, lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa), 76 kDa tyrosine phosphoprotein, SH2 domain-conta
Mouse
IgG2a
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3937
Documents
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