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SLP76 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA119378

Catalog No. 01-676-751


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Description

Description

SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets; B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.
Specifications

Specifications

SLP76
Polyclonal
PBS with 15mM sodium azide; pH 7.4
Q13094
LCP2
Rabbit
IgG
100 μg
4° C, do not freeze
Primary
3937
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
LCP2
Liquid
LCP2
Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human
Documents
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