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SLPI Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520385

Catalog No. PIPA520385


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Description

Description

A suggested positive control is Daudi cell lysate. PA5-20385 can be used with blocking peptide PEP-0502.

Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-kappa-B activation by inhibiting Ikappa-B degradation in the cytoplasm and competing for NF-kappa-B binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.
Specifications

Specifications

SLPI
Polyclonal
Unconjugated
SLPI
Liquid
SLPI
A 17 amino acid peptide from near the center of human SLPI.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P03973, P97430
ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4; HUSI-1; WAP four-disulfide core domain protein 4; antileukoproteinase; mucus proteinase inhibitor; protease inhibitor WAP4; secretory leukocyte protease inhibitor (antileukoproteinase); seminal proteinase inhibitor
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
20568, 6590
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