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SLUG Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520289

Catalog No. PIPA520289


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Description

Description

A suggested positive control is human kidney tissue lysate. PA5-20289 can be used with blocking peptide PEP-0419.

Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.
Specifications

Specifications

Slug
Polyclonal
Unconjugated
SNAI2
Liquid
SNAI2
A 14 amino acid peptide from near the center of human Slug.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O43623, P97469
SLUG, SLUGH1, SNAIL2, WS2D; neural crest transcription factor SLUG; protein snail homolog 2; slug (chicken homolog), zinc finger protein; zinc finger protein SNAI2
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
20583, 6591
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