SLUG Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520290
A suggested positive control is 293 cell lysate. PA5-20290 can be used with blocking peptide PEP-0420.Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.
|A 13 amino acid peptide from near the center of human Slug.|
|Antigen affinity chromatography|
|Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|SLUG, SLUGH1, SNAIL2, WS2D; neural crest transcription factor SLUG; protein snail homolog 2; slug (chicken homolog), zinc finger protein; zinc finger protein SNAI2|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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