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SMAD2 Goat anti-Human, Mouse, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA19100

Catalog No. 01-674-682


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Description

Description

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed.

This antibody is predicted to react with bovine based on sequence homology.
Specifications

Specifications

SMAD2
Polyclonal
Unconjugated
SMAD2
Liquid
SMAD2
Internal sequence corresponding to amino acids C-SEIWGLSTPNTID.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
peptide-ELISA, Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Q15796, Q62432
MADH2; JV18; MADR2; SMAD2; JV18-1; MAD, mothers against decapentaplegic homolog 2 (Drosophila); Mothers against decapentaplegic, Drosophila, homolog o
Goat
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
17126, 4087
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