MilliporeSigma anti-SMAD7 Clone: 40,
Mouse Monoclonal Antibody
Manufacturer: MilliporeSigma ST1625100UG
Specifically detects SMAD7 Clone: 40 in Human samples, and it is validated for Immuno BlottingSMAD7 protein acts as an antagonist of signaling by TGF-β (transforming growth factor) type 1 receptor superfamily members, which has been shown to inhibit TGF-β (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. It functions as an adapter to recruit SMURF2 to the TGF-β receptor complex. Also, it acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.
|In PBS, pH 7.2.|
|Recognizes the ∽40-45kDa SMAD7 protein in HeLa and U-2 OS cells and human placenta tissue.|
|Immuno Blotting, Immunoblot|
|A recombinant polypeptide corresponding to amino acids of 160-261 human SMAD7, expressed as a GST fusion protein|
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