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MilliporeSigma™ anti-SMAD7 Clone: 40,

Mouse Monoclonal Antibody

Manufacturer:  MilliporeSigma™ ST1625100UG

Catalog No. ST1625100UG


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Description

Description

Specifically detects SMAD7 Clone: 40 in Human samples, and it is validated for Immuno Blotting

SMAD7 protein acts as an antagonist of signaling by TGF-β (transforming growth factor) type 1 receptor superfamily members, which has been shown to inhibit TGF-β (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. It functions as an adapter to recruit SMURF2 to the TGF-β receptor complex. Also, it acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.
Specifications

Specifications

SMAD7
40
In PBS, pH 7.2.
Murine
IgG2a
RUO
Primary
Recognizes the ∽40-45kDa SMAD7 protein in HeLa and U-2 OS cells and human placenta tissue.
Immuno Blotting, Immunoblot
Unconjugated
Purified
A recombinant polypeptide corresponding to amino acids of 160-261 human SMAD7, expressed as a GST fusion protein
100μg
−20°C
Monoclonal
Human
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