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SMC1 Mouse anti-Human, Clone: C2M, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112604

Catalog No. 01-674-371


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Description

Description

A suggested positive control for this product is HeLa cells.

Structural Maintece of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromo proteins are conserved in eukaryotes lead to mitotic chromosome segregatior defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. A number of cellular factors interact with hSMC1/hSMC3 during cell cycle. The major population of hSMC1/hSMC3 is in a compex with hRAD21 forming the human cohesion complex. Human cohesion associates with chromosomes which peaks at S phase and dissociates from chromosomes during G2/M transition. In addition, a subpopulation of hSMC1/hSMC3 associates tightly with nuclear matrix and centrosomes during interphase. A subset of hSMC1/hSMC3 is localized to spindle poles, spindles, and kinetochores during mitosis when cohesin is in the cytoplasm. hSMC1/hSMC3 is required for spindle aster formation in vitro and reacts with nuclear mitotic apparatus protein in vivo.
Specifications

Specifications

SMC1
Monoclonal
1 mg/mL
PBS with 0.08% sodium azide
Q14683
RP6-29D12.1, CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Mouse
Protein A/G
RUO
Antibody
Monoclonal
Human
Immunofluorescence, Western Blot
C2M
Unconjugated
SMC1A
Liquid
SMC1A
Recombit protein corresponding to aa 402-894 of human SMC1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
8243
Documents
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