SMC1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA529691
PA5-29691 targets SMC1A in IHC (P) and WB applications and shows reactivity with Human and mouse samples. The PA5-29691 immunogen is recombit fragment corresponding to a region within amino acids 308 and 546 of Human SMC1A. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintece of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.
|Recombit fragment corresponding to a region within amino acids 308 and 546 of Human SMC1A|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7|
|CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB, SMC protein 1A, SMC-1-alpha, SMC-1A, SMC1 (structural maintece of chromosomes 1, yeast)-like 1, SMC1 structural maintece of chromosomes 1-like 1, segregation of mitotic chromosomes 1, structural maintece of chromosomes protein 1A|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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