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SMO Rabbit anti-Human, Mouse, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141500

Catalog No. 01-675-325

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with zebrafish samples based on sequence homology.

Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by  b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.
Specifications

Specifications

SMO
Polyclonal
Unconjugated
SMO
Liquid
SMO
Synthetic peptide corresponding to residues 190-240 of human SMOH.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Non-human primate
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 0.05% sodium azide
Q99835, P56726
SMOH
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
319757, 6608
Documents
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