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SMURF2 Mouse anti-Human, Mouse, Rat, Clone: 690638, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524314

Catalog No. PIMA524314


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Description

Description

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Specifications

Specifications

SMURF2
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q9HAU4, A2A5Z6
E3 ubiquitin ligase SMURF2, E3 ubiquitin-protein ligase SMURF2, SMAD ubiquitination regulatory factor 2, SMAD-specific E3 ubiquitin-protein ligase 2, hSMURF2
Mouse
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
303614, 64750, 66313
Western Blot
690638
Unconjugated
SMURF2
Lyophilized
SMURF2
E. coli-derived recombit human SMURF2 Met490-Glu748
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
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