SMURF2 Mouse anti-Human, Mouse, Rat, Clone: 690638, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524314
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
|PBS with 5% trehalose and No Preservative|
|E3 ubiquitin ligase SMURF2, E3 ubiquitin-protein ligase SMURF2, SMAD ubiquitination regulatory factor 2, SMAD-specific E3 ubiquitin-protein ligase 2, hSMURF2|
|-20° C, Avoid Freeze/Thaw Cycles|
|303614, 64750, 66313|
|E. coli-derived recombit human SMURF2 Met490-Glu748|
|Human, Mouse, Rat|
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